S7201

SR-46349 hemifumarate salt

≥98% (HPLC)

• Synonym(e): 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt, Eplivanserin hemifumarate salt, SR-46349B
• Empirische Formel (Hill-System): C₁₉H₂₁FN₂O₂ · 0.5 C₄H₄O₄
• CAS-Nummer: 130580-02-8
• Molekulargewicht: 386.42
• NACRES: NA.77
• PubChem Substance ID: 329824579
• UNSPSC Code: 12352200
• MDL number: MFCD12546335
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C=C\C(O)=O.CN(C)CCO\N=C(\C=C\c1ccc(O)cc1)c2ccccc2F.CN(C)CCO\N=C(\C=C\c3ccc(O)cc3)c4ccccc4F
• InChI: 1S/2C19H21FN2O2.C4H4O4/c2*1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15;5-3(6)1-2-4(7)8/h2*3-12,23H,13-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b2*12-9+,21-19-;2-1+
• InChI key: RNLKLYQQDLHHBH-ABDBJYMXSA-N
• Gene Information: human ... HTR2A(3356)

Beschreibung

Application

SR-46349 hemifumarate salt may be used in cell signaling studies.

Biochem/physiol Actions

ASTAR (Antagonist of Serotonin 5HT2A Receptors).

SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.¹ It increases the signal transduction induced by 5-HT₂ receptor by binding with high affinity.² SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.³

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H302,H410
• Sicherheitshinweise: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable