S8010

(±)-Sulpirid

D2 dopamine antagonist, powder

• Synonym(e): (±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide
• Empirische Formel (Hill-System): C₁₅H₂₃N₃O₄S
• CAS-Nummer: 15676-16-1
• Molekulargewicht: 341.43
• NACRES: NA.77
• PubChem Substance ID: 24277933
• UNSPSC Code: 12352200
• EC Number: 239-753-7
• MDL number: MFCD00055061
• Form: powder

Eigenschaften

• Produktname: (±)-Sulpirid,
• form: powder
• Quality Segment: 100
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL, 0.1 M HCl: soluble, H₂O: slightly soluble, ethanol: soluble
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
• InChI: 1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
• InChI key: BGRJTUBHPOOWDU-UHFFFAOYSA-N
• Gene Information: human ... CA1(759), CA2(760), CA4(762), CA5A(763), CA5B(11238), CA9(768), DRD2(1813)

Beschreibung

Application

(±)-Sulpiride was used to study the effect of dopamine D₂ receptor signaling on calcium channels in rat pituitary melanotropic cells.⁴⁷

Biochem/physiol Actions

(±)-Sulpiride is a D₂ dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D₂-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.^45,46

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• Gefahrencodes: H361
• Sicherheitshinweise: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable