SML0128

M30 dihydrochloride

≥98% (HPLC)

• Synonym(e): 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride
• Empirische Formel (Hill-System): C₁₄H₁₄N₂O · 2HCl
• CAS-Nummer: 64821-19-8
• Molekulargewicht: 299.20
• NACRES: NA.77
• PubChem Substance ID: 329825178
• UNSPSC Code: 12352200
• MDL number: MFCD20488063
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: green-yellow
• solubility: DMSO, heptane and xylene: ≥21 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
• InChI: 1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H
• InChI key: XJNICPXVRPOSSO-UHFFFAOYSA-N

Beschreibung

Application

M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.

Biochem/physiol Actions

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Site-activated iron chelator and monoamine oxidase (MAO) inhibitor; neuroprotective and anti-apoptotic

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• Gefahrencodes: H302,H318
• Sicherheitshinweise: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable