SML0283

Amorolfin -hydrochlorid

≥98% (HPLC), Ergosterol biosynthesis inhibitor, powder

• Synonym(e): (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)-phenyl]-2-methylpropyl]-2,6-dimethylmorpholin -hydrochlorid
• Empirische Formel (Hill-System): C₂₁H₃₅ON · HCl
• CAS-Nummer: 78613-38-4
• Molekulargewicht: 353.97
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825291
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Amorolfin -hydrochlorid, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: ≥5 mg/mL (warmed)
• storage temp.: room temp
• SMILES string: Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
• InChI: 1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
• InChI key: XZKWIPVTHGWDCF-KUZYQSSXSA-N

Beschreibung

Application

Amorolfine hydrochloride has been used as an antifungal agent.

Biochem/physiol Actions

Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.

Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.

Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H302,H315,H411
• Sicherheitshinweise: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable