SML0346

Alosetron hydrochloride

≥98% (HPLC)

• Synonym(e): 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₈N₄O·HCl
• CAS-Nummer: 122852-69-1
• Molekulargewicht: 330.81
• NACRES: NA.77
• PubChem Substance ID: 329825350
• UNSPSC Code: 12352200
• MDL number: MFCD09028027
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: ≥5 mg/mL at warmed
• storage temp.: 2-8°C
• SMILES string: CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl
• InChI: 1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H
• InChI key: FNYQZOVOVDSGJH-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Beschreibung

Biochem/physiol Actions

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

Alosetron is a potent and highly selective antagonist.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301,H319,H412
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Sicherheitshinweise: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313