SML0568

3-AP

≥98% (HPLC)

• Synonym(e): 3-AP, 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone, PAN-811
• Empirische Formel (Hill-System): C₇H₉N₅S
• CAS-Nummer: 143621-35-6
• Molekulargewicht: 195.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 meq/mL, clear
• storage temp.: 2-8°C
• SMILES string: S=C(N\N=C\c1ncccc1N)N
• InChI: 1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
• InChI key: XMYKNCNAZKMVQN-NYYWCZLTSA-N

Beschreibung

Biochem/physiol Actions

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.

3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC₅₀ value of 0.3μM. It exhibits anti-proliferative activity in preclinical models of cancer, such as lung cancer. It also has an ability to increase the cytotoxicity, intracellular uptake and DNA incorporation of gemcitabine in vitro.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301,H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable