SML0646

GMX1778

≥98% (HPLC), nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, powder

• Synonym(e): CHS 828, CHS-828, GMX 1778, N-[6-(4-Chlorophenoxy)hexyl]-N′-cyano-N′′-4-pyridinyl-guanidine
• Empirische Formel (Hill-System): C₁₉H₂₂ClN₅O
• CAS-Nummer: 200484-11-3
• Molekulargewicht: 371.86
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: GMX1778, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Clc1ccc(cc1)OCCCCCCN\C(=N\C#N)\Nc2ccncc2
• InChI: 1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
• InChI key: BOIPLTNGIAPDBY-UHFFFAOYSA-N

Beschreibung

Application

GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.

Biochem/physiol Actions

GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells.

GMX1778 is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).

GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable