SML0756

IDT307

≥98% (HPLC), DAT, NET and SERT substrate, powder

• Synonym(e): 4-(4-Dimethylamino)phenyl-1-methylpyridinium iodide, 4-[p-(Dimethylamino)phenyl]-1-methylpyridinium iodide, APP+
• Empirische Formel (Hill-System): C₁₄H₁₇N₂ · I
• CAS-Nummer: 1141-41-9
• Molekulargewicht: 340.20
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: IDT307, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: , orange to dark orange-red
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [I-].[n+]1(ccc(cc1)c2ccc(cc2)N(C)C)C
• InChI: 1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1
• InChI key: CAMWVBRDIKKGII-UHFFFAOYSA-M

Beschreibung

Biochem/physiol Actions

IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+ monoamine transporter substrate that fluoresces after uptake into cells. IDT307 is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). IDT307 (APP+) was found to label catecholamine neuronal cell bodies with high selectivity in midbrain and was used to investigate SERT function in lymphocytes and platelets.

IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H300
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable