SML0782

(-)-Umbellulone

≥98% (HPLC)

• Synonym(e): (1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one, (1R,5S)-(-)-3-Thujen-2-one, Thujen-2-one, Thujenone
• Empirische Formel (Hill-System): C₁₀H₁₄O
• CAS-Nummer: 546-78-1
• Molekulargewicht: 150.22
• UNSPSC Code: 12352202
• Assay: ≥98% (HPLC)
• Form: oil
• Storage condition: desiccated

Eigenschaften

• biological source: Umbellularia californica Nutt.
• assay: ≥98% (HPLC)
• form: oil
• storage condition: desiccated
• color: colorless to light brown
• storage temp.: −20°C
• SMILES string: O=C1[C@@]2([C@@H](C2)C(=C1)C)C(C)C
• InChI: 1S/C10H14O/c1-6(2)10-5-8(10)7(3)4-9(10)11/h4,6,8H,5H2,1-3H3/t8-,10+/m0/s1
• InChI key: LTTVJAQLCIHAFV-WCBMZHEXSA-N

Beschreibung

Biochem/physiol Actions

(-)-Umbellulone is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels.

(-)-Umbellulone, isolated from the"headache tree" Umbellularia californica Nutt, is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. (-)-Umbellulone activates TRPA1 channels on nociceptive trigeminal afferents, resulting in release of CGRP and CGRP-mediated neurogenic vasodilatation, causing a painful cold sensation and headache/migraine.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable