SML1073

BIX

≥98% (HPLC), molecular chaperone GRP78 inducer, powder

• Synonym(e): 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid, BiP protein Inducer X
• Empirische Formel (Hill-System): C₉H₇NO₃S
• CAS-Nummer: 101714-41-4
• Molekulargewicht: 209.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825455
• NACRES: NA.77
• MDL number: MFCD22415334
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: BIX, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=C(O)C=C(C(CSC#N)=O)C=C1
• InChI: 1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2
• InChI key: SVFLBLCWKKQKDW-UHFFFAOYSA-N

Beschreibung

Application

BIX has been used in cell viability assay.

Biochem/physiol Actions

BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.

BIX is an inducer of molecular chaperone GRP78 (BIP, Glucose regulated protein 78).

Other Notes

air sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Gefahrencodes: H302,H315,H317,H319
• Sicherheitshinweise: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1