SML1074

R1530

≥98% (HPLC)

• Synonym(e): 5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine
• Empirische Formel (Hill-System): C₁₈H₁₄ClFN₄O
• CAS-Nummer: 882531-87-5
• Molekulargewicht: 356.78
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825456
• MDL number: MFCD23704870
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: , white to yellow to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=CC=C1C2=NC3=C(C)NN=C3NC4=C2C=C(F)C(OC)=C4
• InChI: 1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)
• InChI key: UOVCGJXDGOGOCZ-UHFFFAOYSA-N
• Gene Information: human ... AURKA(6790), FGFR1(2260), FGFR2(2263), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), PDGFRB(5159), PLK4(10733)

Beschreibung

Biochem/physiol Actions

R1530 is a multi-kinase inhibitor and an anti tumor agent.

R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable