SML1332

NG25 trihydrochloride

≥98% (HPLC)

• Synonym(e): N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride, NG 25 trihydrochloride
• Empirische Formel (Hill-System): C₂₉H₃₀F₃N₅O₂ · 3HCl
• CAS-Nummer: 1315355-93-1
• Molekulargewicht: 646.96
• NACRES: NA.77
• PubChem Substance ID: 329825790
• UNSPSC Code: 12352200
• MDL number: MFCD19443255
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1OC4=C(C=CN5)C5=NC=C4
• InChI: 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
• InChI key: SMPGEBOIKULBCT-UHFFFAOYSA-N

Beschreibung

Application

NG25 trihydrochloride has been used as a transforming growth factor β (TGFβ)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.

Biochem/physiol Actions

NG25 is multiple kinase inhibitor; potent dia; omjobotpr pf TAK1 and MAP4K2 kinases.

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

Other Notes

Light sensitive

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301,H413
• Sicherheitshinweise: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable