SML1880

SPL-334

≥98% (HPLC)

• Synonym(e): 4-{[2-[(2-Cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
• Empirische Formel (Hill-System): C₂₂H₁₅N₃O₃S₂
• CAS-Nummer: 688347-51-5
• Molekulargewicht: 433.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD05032783
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O
• InChI key: UWWSCLNCHCROLL-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.

SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR).

Sicherheitshinweise

• Gefahrencodes: H413
• Sicherheitshinweise: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3