The solubility test points, not upper limits, are as follows:
- DMF: 5 mg/ml
- DMSO: 5 mg/ml
- PBS (pH 7.2) (1:6): 0.1 mg/ml
- Ethanol: 3 mg/ml
Fortfahren mit
SML2480
Mirabegron
≥98% (HPLC), β3-adrenoceptor agonist, powder
Synonym(e):
2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[2-[((2R)-2-hydroxy-2-phenylethyl)amino]ethyl]phenyl]acetamide, 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide, YM 178, YM178(R)-Mirabegron
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 106,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 429,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C21H24N4O2S
CAS-Nummer:
Molekulargewicht:
396.51
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Mirabegron, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -16 to -22°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O[C@@H](CNCCC1=CC=C(NC(CC2=CSC(N)=N2)=O)C=C1)C3=CC=CC=C3
InChI
1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChI key
PBAPPPCECJKMCM-IBGZPJMESA-N
Application
Mirabegron has been used as a β3-adrenergic receptor (β3-AR) agonist in an in vitro experiment to determine whether β3-AR stimulation specifically activates brown adipose tissue (BAT) thermogenesis in humans.
Biochem/physiol Actions
Mirabegron is a non-antimuscarinic orally active drug with the potential to treat patients with overactive bladder (OAB) symptoms. It aids in bladder relaxation by acting on neural control of the storage phase of micturition by targeting β3-AR. Mirabegron is also used to treat neurogenic detrusor overactivity (NDO) in pediatric patients.
Mirabegron is a potent and selective β3-adrenoceptor agonist that activates the β3 adrenergic receptor in the detrusor muscle in the bladder leading to muscle relaxation and an increase in bladder capacity.
potent and selective β3-adrenoceptor agonist
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description CRS, European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard | description - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form - | form - | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-30°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
| optical activity [α]/D -16 to -22°, c = 0.5 in methanol | optical activity - | optical activity - | optical activity - |
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Signalwort
Warning
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Repr. 2
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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What is the solubility of item SML2480, Mirabegron?
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