They wouldn't tell me what the thing is dissolved in, preventing me from having the proper vehicle control for experimentation. Disappointing service.
Fortfahren mit
SML2709
Sphingosine 1-phosphate
≥95% (TLC), liquid, Lipid second messenger
Synonym(e):
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate, S1P
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
0.1 mL | Warenkorb auf Verfügbarkeit prüfen | € 112,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C18H38NO5P
Molekulargewicht:
379.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (TLC)
Form:
liquid
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenProduktname
Sphingosine 1-phosphate ready made solution, ≥95% (TLC), Fully soluble 10mM solution
Quality Segment
assay
≥95% (TLC)
form
liquid
storage temp.
−20°C
General description
Sphingosine 1-phosphate (S1P) is a sphingolipid derived from ceramide by an enzymatic reaction in vivo.1 S1P acts as a signaling molecule by binding to G-protein coupled receptors (S1PR) (S1P1-5 receptors) which results in activation of small GTPases such as Ras, Rac Rho and further downstream intracellular effects such as PI-3-Kinase, Protein kinase C and Hippo signaling pathways. This generates an effect on cell migration, differentiation and survival and therefore effects variety of systems such as immune system, central nervous system and cardiovascular system.2 For instance, S1P was found to inhibit cell apoptosis and induce cell proliferation by binding S1P1 to promote activation of ERK pathway.3 In addition, S1P was found to support cancer cells by inducing angiogenesis and survival of proliferative cells in the tumor microenvironment.4 Due to the vast activities of S1P and the resulted S1PR irregular activation, large discovery efforts are made to identify therapy by S1PR antagonists.5
Biochem/physiol Actions
Anti angigoenesis
Other Notes
Sphingosine 1-phosphate ready made solution is supplied in aqueous solution at 10mM concentration and can be further diluted (X10000) to a working concentration of 1μM.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥95% (TLC), Fully soluble 10mM solution | description ≥98.0% (TLC) | description A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. | description Avanti Research™ - A Croda Brand |
| form liquid | form powder | form solid | form powder |
| assay ≥95% (TLC) | assay ≥98.0% (TLC) | assay ≥95% (elemental analysis) | assay >99% (TLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Lagerklasse
12 - Non Combustible Liquids
Was ist los?
WGK 2
Zulassungslistungen
Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.
109-89-7
CAS No.
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.