SML2909

Nolatrexed dihydrochloride

≥98% (HPLC)

• Synonym(e): 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride, AG 337
• Empirische Formel (Hill-System): C₁₄H₁₂N₄OS · 2HCl
• CAS-Nummer: 152946-68-4
• Molekulargewicht: 357.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD26960887
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O
• InChI: 1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
• InChI key: PJKVJJYMWOCLIJ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.

potent thymidylate synthase inhibitor

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• Gefahrencodes: H341,H361fd
• Sicherheitshinweise: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable