SML3985

JP3000

≥98% (HPLC)

• Synonym(e): JP 3000, JP-3000, trans-2-(5-(3,5-bis(Trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)cyclopropane-1-carboxylic acid
• Empirische Formel (Hill-System): C₂₁H₁₃F₆NO₃
• CAS-Nummer: 3034097-74-7
• Molekulargewicht: 441.32
• NACRES: NA.28
• UNSPSC Code: 12352203
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(O)[C@H]1[C@@H](C1)C2=NC(C3=CC=CC=C3)=C(O2)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Beschreibung

Biochem/physiol Actions

Potent and selective retinoid X receptors (RXRs) agonist that activates cellular RXR homodimer as well as RXR:RAR heterodimer.

JP3000 is a potent and selective retinoid X receptors agonist (EC50/Emax = 5 nM/38-fold/RXRα 1.4 nM/69-fold/RXRβ, 4 nM/24-fold/RXRγ) with >100-fold selecivity for RXR over a panel of 27 other nuclear receptors (little or no activation at 1 µM). JP3000 activates cellular RXR homodimer as well as RXR:RAR heterodimer (EC50 = 2.6 and 29 nM, respectively), and induces RXR-regulated GDE1 gene expression (by 2.3-fold/10 nM & 3.6-fold/100 nM).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable