SML4086

NitroSynapsin hydrochloride

≥98% (HPLC)

• Synonym(e): (1s,3r,5R,7S)-3-Amino-5,7-diethyladamantan-1-yl nitrate hydrochloride, 3-amino-5,7-diethyl-tricyclo[3.3.1.13,7]decan-1-ol 1-nitrate hydrochloride, NMI 6979 hydrochloride, NMT3 hydrochloride, NitroMemantine hydrochloride, YQW 036 hydrochloride
• Empirische Formel (Hill-System): C₁₄H₂₄N₂O₃·HCl
• CAS-Nummer: 2445248-27-9
• Molekulargewicht: 304.81
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: N[C@]1(C2)C[C@@]3(CC)C[C@]2(O[N+]([O-])=O)C[C@](C1)(CC)C3.Cl

Beschreibung

Biochem/physiol Actions

Extrasynaptic eNMDAR-selective blocker (over synaptic sNMDAR) with improved efficacy than memantine in cultures and in vivo; potent inhibitor of the SARS-CoV-2 virus entry.
NitroSynapsin is an NMDAR blocker that preferentially targets extrasynaptic over synaptic NMDA receptors (eNMDAR over sNMDAR) via a dual allosteric mechanism of open-channel blockage and NO/redox modulation. NitroSynapsin is significantly more effective than memantine (5 µM) in inhibiting the activation of rat cotical neurons due to NMDA release from co-cultured astrocytes upon stimulation by Aβ1-42 oligomers. When administered in the triple transgenic (3× tg) AD mouse model in vivo (216 mmol/kg bid. ip.), NitroSynapsin, but not memantine, significantly improves the location-novelty recognition. It is a potent inhibitor of the SARS-CoV-2 virus entry that prevents the virus spike protein binding to ACE2 (angiotensin-converting enzyme 2).

Disclaimer

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301,H315
• Sicherheitshinweise: P264 - P280 - P301 + P310 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Skin Irrit. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable