SML4093

GSK205 hydrobromide

>98% (HPLC)

• Synonym(e): GSK 205 hydrobromide, GSK-205 hydrobromide, N-(4-(2-(Benzyl(methyl)amino)ethyl)phenyl)-5-(pyridin-3-yl)thiazol-2-amine hydrobromide, N-(4-{2 [Methyl(phenylmethyl)amino]ethyl}phenyl)-5-(3-pyridinyl)-1,3-thiazol-2-amine hydrobromide
• Empirische Formel (Hill-System): C₂₄H₂₄N₄S · xHBr
• Molekulargewicht: 400.54 (free base basis)
• NACRES: NA.21
• Assay: >98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: >98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Selective transient receptor potential cation channel TRPV4 blocker in cultures and in vivo.


GSK205 is a selective transient receptor potential cation channel TRPV4 blocker that prevents hyposmotic stress-, as well as TRPV4 activator 4αPDD-induced Ca2+ response (IC50 = 600 nM against 10 µM 4αPDD (EC50 = 2 µM); porcine articular chondrocytes). GSK205 upregulates the expression of thermogenic genes in 3T3-F442A adipocyte cultures (5 µM for 4 days) and in diet-induced obese (DIO) mice in vivo (10 mg/kg b.i.d. i.p.)

Disclaimer

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable