SML4206

DMXAA sodium salt

≥98% (HPLC)

• Synonym(e): 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid sodium salt; sodium 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetate, 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid sodium salt; 5,6-Dimethylxanthenone-4-acetic acid sodium salt, Vadimezan sodium salt, ASA404 sodium salt, NSC 640488 sodium salt
• Empirische Formel (Hill-System): C₁₇H₁₃NaO₄
• CAS-Nummer: 129095-08-5
• Molekulargewicht: 304.27
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

A water-soluble sodium salt form of DMXAA. DMXAA directly binds to murine STING (stimulator of interferon genes) but does not affect human STING. DMXAA disrupts tumor vasculature by inducing endothelial cell apoptosis, causing tumor hemorrhagic necrosis and ischemia, releasing serotonin, stimulating the innate immune system, producing inflammatory cytokines (e.g., TNF, IL-6, GCSF, KC, IP-10, MCP-1), activating NF-κB and p38 MAPK, producing nitric oxide, and reducing tumor energetics and membrane turnover.

Disclaimer

Hygroscopic Store with desiccant

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable