SML4244

GSK0660

≥98% (HPLC), powder, PPARβ/δ antagonist

• Synonym(e): 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester, Methyl 3-({[2-(methoxy)-4 phenyl]amino}sulfonyl)-2-thiophenecarboxylate, GSK 0660, GSK-0660
• Empirische Formel (Hill-System): C₁₉H₁₈N₂O₅S₂
• CAS-Nummer: 1014691-61-2
• Molekulargewicht: 418.49
• MDL number: MFCD12828770
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Application

GSK0660 may be used in cell viability assay, real time cell index analysis, and oxyblot assays to study its neuroprotective effect on Parkinson’s disease model in vivo and in vitro.

Biochem/physiol Actions

GSK0660 is a potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) and PPARbeta antagonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available