SML4298

STING degrader AK59

≥98% (HPLC)

• Synonym(e): AK59, AK59-51TB, N-(5-(pyridin-3-yl)quinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide
• Empirische Formel (Hill-System): C₂₁H₁₄F₃N₃O₂S
• Molekulargewicht: 429.41
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

STING degrader AK59 is a potent inhibitor of the cGAS/STING pathway (IC50 = 5.19 µM) by induction of STING interaction with ligase HERC4 (a HECT-domain E3 ligase) followed by degradation of STING. AK59 facilitates HERC4 to transfer ubiquitin directly to Lysine 150 of STING, which initiates the degradation. It is effective against wild-type STING and STING-associated vasculopathy (SAVI) mutant STING proteins in human CD14+ monocytic cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable