SML4351

6PPD-Quinone

≥95% (HPLC)

• Synonym(e): 6-PPD-Quinone, 6PPDQ, 6-PPDQ, 6PPD-Q
• Empirische Formel (Hill-System): C₁₈H₂₂N₂O₂
• CAS-Nummer: 2754428-18-5
• Molekulargewicht: 298.38
• MDL number: MFCD34561806
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: pink to dark red
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

6PPD-quinone (6PPDQ), a highly toxic tire antioxidant 6PPD derivative, bioaccumulates in lipid-rich tissues. 6PPD-Q primarily disrupts vascular permeability (potentially the blood-brain barrier) and induces mitochondrial dysfunction, causing oxidative stress. Molecularly, 6-PPDQ targets cannabinoid receptors (notably high-affinity CNR2), affects neuronal glycolysis, TCA intermediates, and promotes α-synuclein aggregation in vitro. Cellular/biological outcomes include dose-dependent mammalian multi-organ toxicity (hepatic, enteric, pulmonary, neuro-, reproductive [PCOS-linked], cardiac). In vivo, its extreme relevance is evident in potent salmonid lethality (e.g., Coho salmon LC50: 0.041 µg/L).

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H302,H317,H410
• Sicherheitshinweise: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable