SML4374

HuR Molecular Glue Degrader, MG-HuR2

≥98% (HPLC)

• Synonym(e): Ethyl (E)-5-(4-(4-methoxyphenyl)-4-oxobut-2-enamido)-1H-indole-2-carboxylate, MG-HuR2
• Empirische Formel (Hill-System): C₂₂H₂₀N₂O₅
• CAS-Nummer: 3098773-64-6
• Molekulargewicht: 392.40
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to light orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

MG-HuR2 is a cell-permeable, druglike molecular glue that potently degrades the oncogenic RNA-binding protein HuR (DC₅₀ ≈ 5-10 nM in breast cancer cells) by recruiting the RNF126 E3 ligase. MG-HuR2’s strategic advantage lies in a novel dual-engagement mechanism, binding two distinct RNA-binding pockets (P1/P2) on HuR to drive a unique biphasic degradation profile, enabling more comprehensive and sustained target suppression than conventional inhibitors. This degradation cascade effectively downregulates key HuR-target mRNAs, reducing Bcl2 protein levels by up to 88% at a 10 nM concentration. Functionally, this translates to potent inhibition of cancer cell proliferation, induction of apoptosis, and the arrest of 3D spheroid growth. Given its favorable safety profile and precision mechanism, MG-HuR2 emerges as a powerful chemical tool for interrogating RNA biology and a promising therapeutic candidate for HuR-driven cancers.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H317
• Sicherheitshinweise: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable