SML4378

HSL119

≥98% (HPLC)

• Synonym(e): 3-((8-Amino-1,7-naphthyridin-5-yl)ethynyl)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• Empirische Formel (Hill-System): C₃₀H₂₇F₃N₆O
• CAS-Nummer: 2231745-56-3
• Molekulargewicht: 544.57
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

HSL119 is a cell penetrant, potent and selective inhibitor of HUNK kinase (hormonally upregulated neu-associated kinase) that completely blocks phosphorylation of the Rubicon S92 in vitro. HSL119 decreases Rubicon S92 phosphorylation and potently inhibits survival of patient driven JIMT-1 cells (HER2+ breast cancer cells) (IC50 = 1.7µM in JIMT-1 cells). HSL119 exhibits substantial efficacy toward HER2+ breast cancer. Additionally, HSL119 inhibits ABL1, BRAF, FLT3, and RET kinases.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• Gefahrencodes: H301,H360FD,H372
• Sicherheitshinweise: P202 - P260 - P264 - P280 - P301 + P310 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 1B - STOT RE 1 Dermal
• Zielorgane: Liver,Bone marrow,Pancreas,Cardio-vascular system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable