SML4411

N6F11

≥98% (HPLC)

• Synonym(e): 2-(Chloromethyl)-6-(4-chlorophenyl)-1H-thieno[3,2-d]pyrimidin-4-one, 2-(Chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one, 2-(Chloromethyl)-6-(4-chlorophenyl)-thieno[3,2-d]pyrimidin-4(1H)-one, 2-(Chloromethyl)-6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one
• Empirische Formel (Hill-System): C₁₃H₈Cl₂N₂OS
• CAS-Nummer: 851398-76-0
• Molekulargewicht: 311.19
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

N6F11 is a ferroptosis inducer (0.5-10 µM for 24h) that causes cellular glutathione peroxidase 4 (GPX4) degradation (5 µM for 6-12h, 0.0625-5 µM for 12h) via ubiquitin-proteasome system (UPS) by inducing TRIM25-mediated ubiquitination. N6F11 causes ferroptotic cancer cell death that initiates HMGB1-dependent antitumor immunity mediated by CD8+ T-cells. When administered together with CD274 neutralizing antibody (clone 10F.9G2), N6F11 prolongs the average life expectancy of KPC mice, an orthotopic pancreatic ductal adenocarcinoma (PDA) model in vivo (10 mg N6F11/kg, 20 mg αCD274/kg via i.p.). Unlike RSL3, Fin56, and erastin, autophagy is dispensable of N6F11-induced ferroptosis.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable