T2379

Tubocurarin

≥97%, neuromuscular blocker

• Synonym(e): (+)-Tubocurarine hydrochloride
• Empirische Formel (Hill-System): C₃₇H₄₁ClN₂O₆ · HCl · 5H₂O
• CAS-Nummer: 6989-98-6
• Molekulargewicht: 771.72
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900034
• NACRES: NA.77
• MDL number: MFCD00150157
• Assay: ≥97%

Eigenschaften

• Produktname: Tubocurarin, ≥97%
• Quality Segment: 200
• assay: ≥97%
• solubility: H₂O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow, ethanol: soluble, methanol: soluble
• storage temp.: 2-8°C
• SMILES string: O.O.O.O.O.Cl.[Cl-].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
• InChI: 1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1
• InChI key: WMIZITXEJNQAQK-GGDSLZADSA-N
• Gene Information: human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

Beschreibung

Application

Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes, muscle and as neuromuscular junction blocker in zebra fish embryos.

Biochem/physiol Actions

Tubocurarine is a muscle relaxant and a nicotinic acetylcholine receptor antagonist. It can induce neuromuscular blocking.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 + P330 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges