T4577

Terodiline hydrochloride

≥98% (HPLC), solid

• Synonym(e): Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride
• Empirische Formel (Hill-System): C₂₀H₂₇N·HCl
• CAS-Nummer: 7082-21-5
• Molekulargewicht: 317.90
• NACRES: NA.77
• PubChem Substance ID: 329826797
• UNSPSC Code: 12352200
• MDL number: MFCD00941402
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: −20°C
• SMILES string: Cl.CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C
• InChI: 1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H
• InChI key: RNGHAJVBYQPLAZ-UHFFFAOYSA-N
• Gene Information: human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133) ;

Beschreibung

Biochem/physiol Actions

Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.

Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermore, terodiline hydrochloride has been linked to cardiac arrhythmias¹.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Terodiline hydrochloride is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H302,H319,H400
• Sicherheitshinweise: P273 - P301 + P312 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Faceshields, Gloves