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T4680

Terazosin hydrochloride

≥98% (TLC), α1-adrenoceptor antagonist, powder

Synonym(e):

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride

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Größe/SKUVerfügbarkeitPreis
50 mg
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€ 169,00
250 mg
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€ 733,00

Über diesen Artikel

Empirische Formel (Hill-System):
C19H25N5O4 · HCl
CAS-Nummer:
Molekulargewicht:
423.89
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder

€ 169,00


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Produktname

Terazosin hydrochloride, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow, methanol: 20 mg/mL, clear, colorless, ethanol: 4 mg/mL

originator

Abbott

SMILES string

Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4

InChI

1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H

InChI key

IWSWDOUXSCRCKW-UHFFFAOYSA-N

Gene Information

General description

Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.

Application

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.

Biochem/physiol Actions

α1-adrenoceptor antagonist.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

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Dieser Artikel
Y0000621PHR17211643452
description

≥98% (TLC), powder

description

European Pharmacopoeia (EP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

United States Pharmacopeia (USP) Reference Standard

assay

≥98% (TLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

-

solubility

methanol: 20 mg/mL, clear, colorless, H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow, ethanol: 4 mg/mL

solubility

-

solubility

-

solubility

-

color

white to off-white

color

-

color

-

color

-

originator

Abbott

originator

-

originator

-

originator

-


Piktogramme

Exclamation mark

Signalwort

Warning

Gefahrencodes

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

dust mask type N95 (US), Eyeshields, Gloves



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Questions

  1. Can this product be frozen in saline solution and thawed for later use? For how long is the product stable in solution or should it be made fresh prior to use?

    1 answer
    1. Unfortunately, solution stability studies of this product have not been performed. However, other sources state that this chemical is stable when stored at -20°C for up to 3 months. Avoid repeated freeze/thaw cycles.
      Please see the link below to review the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/132/566/t4680pis.pdf

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