T7580

TN-16

≥98% (HPLC)

• Synonym(e): 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione, NSC 239274
• Empirische Formel (Hill-System): C₁₉H₁₈N₂O₂
• CAS-Nummer: 33016-12-5
• Molekulargewicht: 306.36
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826871
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥17 mg/mL
• storage temp.: 2-8°C
• SMILES string: C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O
• InChI: 1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-
• InChI key: KWSXUGYAGMSUTN-LGMDPLHJSA-N

Beschreibung

Application

TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines .

Biochem/physiol Actions

Inhibitor of microtubule assembly

TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.

3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor that could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H317,H400
• Sicherheitshinweise: P273 - P280 - P302 + P352
• Hazard Classifications: Aquatic Acute 1 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable