U100

Urapidil hydrochloride

solid

• Synonym(e): 6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
• Empirische Formel (Hill-System): C₂₀H₂₉N₅O₃ · HCl
• CAS-Nummer: 64887-14-5
• Molekulargewicht: 423.94
• NACRES: NA.77
• PubChem Substance ID: 24277811
• UNSPSC Code: 12352200
• MDL number: MFCD00078601
• Form: solid

Eigenschaften

• form: solid
• color: white
• solubility: H₂O: soluble 25 mg/mL, clear, colorless to very faintly yellow
• SMILES string: Cl[H].COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
• InChI: 1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
• InChI key: KTMLZVUAXJERAT-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), HTR1A(3350)

Beschreibung

General description

The adrenoreceptor α 1a gene (ADRA1A) is mapped to human chromosome 8p21.2. It codes for an α-adrenergic receptor.

Biochem/physiol Actions

α1-adrenoceptor antagonist; 5-HT1A serotonin receptor partial agonist; anti-hypertensive.
The adrenoreceptor α 1a gene (ADRA1A) participates in smooth muscle contraction. It is also required for vasoconstriction of blood vessels throughout the body such as the skin, gastrointestinal system, genitourinary system, kidney and brain. ADRA1A plays a major role in glycogenolysis and gluconeogenesis of adipose tissue in the liver. It also plays a crucial role in sympathetic nervous system.

Preparation Note

Urapidil hydrochloride is soluble in water at 25 mg/ml to yield a clear, colorless to very faint yellow solution.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves