U3385

UA62784

≥98% (HPLC)

• Synonym(e): 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
• Empirische Formel (Hill-System): C₂₃H₁₅NO₃
• CAS-Nummer: 313367-92-9
• Molekulargewicht: 353.37
• NACRES: NA.77
• PubChem Substance ID: 329827627
• UNSPSC Code: 12352202
• MDL number: MFCD00489199
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: >2 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
• InChI: 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• InChI key: SVICLWPFAQYZLX-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable