1437202

Methylpyrrolidon

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 1-Methyl-2-pyrrolidon, 1-Methyl-2-Pyrrolidinon, N-Methyl-2-pyrrolidon, M-PYROL, NMP
• Empirische Formel (Hill-System): C₅H₉NO
• CAS-Nummer: 872-50-4
• Molekulargewicht: 99.13
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750275
• MDL number: MFCD00003193
• Beilstein/REAXYS Number: 106420
• eCl@ss: 25140904

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• vapor density: 3.4 (vs air)
• vapor pressure: 0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)
• form: liquid
• autoignition temp.: 518 °F
• expl. lim.: 9.5 %
• manufacturer/tradename: USP
• refractive index: n20/D 1.47 (lit.)
• bp: 202 °C (lit.), 81-82 °C/10 mmHg (lit.)
• mp: −24 °C (lit.)
• density: 1.028 g/mL at 25 °C (lit.)
• application(s): USP Biologics; pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: CN1CCCC1=O
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

Methylpyrrolidone is a highly polar solvent used in biologics formulations, particularly for drugs that require solubilization of hydrophobic compounds. It facilitates the delivery and stability of poorly soluble biologics by enhancing their dissolution properties. NMP is widely used in drug delivery systems, contributing to more efficient therapeutic delivery.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methylpyrrolidone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• Gefahrencodes: H315,H319,H335,H360D
• Sicherheitshinweise: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 1
• Flammpunkt (°F): 195.8 °F - Pensky-Martens closed cup
• Flammpunkt (°C): 91 °C - Pensky-Martens closed cup