1467848

Nobiletin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-on, 3′, 4′, 5, 6, 7, 8-Hexamethoxyflavone
• Empirische Formel (Hill-System): C₂₁H₂₂O₈
• CAS-Nummer: 478-01-3
• Molekulargewicht: 402.39
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 360887
• MDL number: MFCD03273560
• eCl@ss: 25140904

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• packaging: pkg of 100 mg
• manufacturer/tradename: USP
• application(s): pharmaceutical
• format: neat
• storage temp.: −20°C
• SMILES string: COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• InChI key: MRIAQLRQZPPODS-UHFFFAOYSA-N

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nobiletin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Bitter Orange Young Fruit
• Bitter Orange Young Fruit Powder
• Tangerine Peel
• Tangerine Peel Dry Extract
• Tangerine Peel Powder

Biochem/physiol Actions

Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable