V900429

N-Acetyl-L-Cystein

98%, Vetec^™

• Synonym(e): LNAC, NAC
• Lineare Formel: HSCH₂CH(NHCOCH₃)CO₂H
• CAS-Nummer: 616-91-1
• Molekulargewicht: 163.19
• UNSPSC Code: 12352209
• PubChem Substance ID: 329829836
• EC Number: 210-498-3
• Beilstein/REAXYS Number: 1724426
• MDL number: MFCD00004880

Eigenschaften

• Produktname: N-Acetyl-L-Cystein, Vetec^™, reagent grade, 98%
• grade: reagent grade
• product line: Vetec^™
• assay: 98%
• form: powder
• color: white to off-white
• mp: 106-108 °C (lit.)
• application(s): cell analysis
• storage temp.: 2-8°C
• SMILES string: CC(=O)N[C@@H](CS)C(O)=O
• InChI: 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
• InChI key: PWKSKIMOESPYIA-BYPYZUCNSA-N

Beschreibung

Application

• Antioxidant Assay Development: N-Acetyl-L-cysteine (NAC) is used in the metabolic activation and assessment of cytotoxicity of gramine mediated by CYP3A, showcasing its importance in biochemical assays that measure oxidative stress, a critical factor in IVD reagent development (Gao et al., 2024).


• Cell Differentiation and NF-κB Inhibition: NAC′s role extends to inducing oxidative stress and inhibiting NF-κB pathways, which is crucial for the differentiation of cells in AML treatment. This application demonstrates NAC′s utility in clinical diagnostic reagents aimed at cancer treatment and research (Silva et al., 2024).


• Liver Injury Alleviation: Highlighting its therapeutic applications, NAC is used in alleviating acetaminophen overdose-induced liver injury, underlining its potential use in clinical settings and importance in developing therapeutic IVD assays (Chen et al., 2024).


• Enhanced Cancer Treatment Efficacy: Employed in combination therapies, NAC is used to treat posterior gastric pseudomyxoma peritonei, offering insights into its role as a biochemical agent that enhances the efficacy of cancer treatments in diagnostic and therapeutic applications (Sun et al., 2024).


• Regulation of Cell Cycle and Autophagy: NAC′s interactions with 1-Methoxyisobrassinin in ovarian cancer cells illustrate its capability to modulate cell cycle regulation, apoptosis, and autophagy, underpinning its significant role in the development of biomarker detection assays and other IVD products (Zigová et al., 2024).

Biochem/physiol Actions

Antioxidans und mukolytisches Agens. Erhöht den zellulären Pool an Radikalfängern. Apoptose verhindernde Wirkung in neuronalen Zellen und Apoptose induzierende Wirkung in glatten Muskelzellen wurde beobachtet. Inhibiert HIV Replikation. Fungiert möglicherweise als Substrat für mikrosomale Glutathion-Transferase.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H319
• Sicherheitshinweise: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 13 - Non Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable