Direkt zum Inhalt

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ZUSAMMENFASSUNG

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

Sigma-Aldrich

Schwefel, powder, 99.98% trace metals basis

Sigma-Aldrich

Schwefel, 99.998% trace metals basis

Sigma-Aldrich

Platinschwarz, black, powder, ≤20 μm, ≥99.95% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 1.0 mm, 99.9% trace metals basis

Sigma-Aldrich

Platin, foil, thickness 0.025 mm, 99.9% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.9% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.99% trace metals basis

Sigma-Aldrich

Platin, gauze, 52 mesh, 99.9% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.9% trace metals basis

Sigma-Aldrich

Platin, powder, 99.995% trace metals basis

Sigma-Aldrich

Platin, gauze, 100 mesh, 99.9% trace metals basis

Sigma-Aldrich

Platinschwarz, ≥99.9% trace metals basis

Sigma-Aldrich

Platin, foil, thickness 0.05 mm, 99.99% trace metals basis

Sigma-Aldrich

Schwefel, flakes, ≥99.99% trace metals basis

Platin, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

Sigma-Aldrich

Platin, nanopowder, <50 nm particle size (TEM)

Sigma-Aldrich

Platin, wire, diam. 2.0 mm, 99.9% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.10 mm, 99.99% trace metals basis

Supelco

Schwefel, PESTANAL^®, analytical standard

Sigma-Aldrich

Platin, wire, diam. 0.076 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Platinschwarz, low bulk density, ≥99.9% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.127 mm, 99.99% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.99% trace metals basis

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, thermocouple grade

Sigma-Aldrich

Platin, foil, thickness 0.25 mm, 99.99% trace metals basis

Sigma-Aldrich

Platin, sponge, ≥99.9% trace metals basis

Sigma-Aldrich

Platin, shot, ≤3 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Platin, foil, thickness 1.0 mm, 99.99% trace metals basis

Platin, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.99+%

Sigma-Aldrich

Platin, powder (coarse), 99.99% trace metals basis