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Merck

276855

Dimethyl sulfoxide

anhydrous, ≥99.9%

Dimethyl sulfoxide

Synonym(s):

DMSO

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About This Item

Linear Formula:
(CH3)2SO
CAS Number:
Molecular Weight:
78.13
EC Number:
200-664-3
UNSPSC Code:
12191502
PubChem Substance ID:
Beilstein/REAXYS Number:
506008
MDL number:
Grade:
anhydrous
Assay:
≥99.9%
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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Product Name

Dimethyl sulfoxide, anhydrous, ≥99.9%

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES string

CS(C)=O

grade

anhydrous

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

impurities

<0.005% water

evapn. residue

<0.0005%

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

Quality Level

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1 of 4

This Item
D58795.89569472301
assay

≥99.9%

assay

≥99.5%

assay

≥99.9%

assay

≥99.9%

grade

anhydrous

grade

-

grade

anhydrous

grade

ACS reagent

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: miscible (completely)

solubility

H2O: soluble(lit.), acetone: soluble(lit.), benzene: soluble(lit.), chloroform: soluble(lit.), ethanol: soluble(lit.)

solubility

H2O: miscible (completely)

solubility

-

form

liquid

form

liquid

form

-

form

liquid

mp

16-19 °C (lit.)

mp

16-19 °C (lit.)

mp

16-19 °C (lit.)

mp

16-19 °C (lit.)

Application

Dimethyl Sulfoxide may be used as an oxidant for the conversion of isonitriles into isocyanates.[1] DMSO activated by oxalyl chloride can be used in the oxidation of long-chain alcohols to carbonyls.[2]

Disclaimer

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

General description

Dimethyl Sulfoxide is an apolar protic solvent[3] that is generally used as a reaction medium and reagent in organic reactions.[4][5]

Other Notes

For information on dimethyl sulfoxide miscibility, please visit the following link:
Dimethyl Sulfoxide Miscibility/Immiscibility Table
Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.
The article number 276855-4X2L will be discontinued. Please order the single bottle 276855-2L which is physically identical with the same exact specifications.

Packaging

18 L, 200 L packaged in Pure-Pac® stainless steel containers; 100 mL, 250ml, 1 L, 2 L, 6×1 L packaged in Sure/Seal® bottles

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Certificates of Analysis (COA)

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A Practical Synthesis of Isocyanates from Isonitriles: Ethyl 2-Isocyanatoacetate
Hoang VLe and Ganem B
Organic Syntheses, 89, 404-404 (2012)
Dimethyl sulfoxide oxidations.
Epstein WW & Sweat FW.
Organic Syntheses, 67(3), 247-260 (1967)
The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals
Royal Society of Chemistry null
Oxidation of long-chain and related alcohols to carbonyls by dimethyl sulfoxide" activated" by oxalyl chloride.
Mancuso AJ, et al.
The Journal of Organic Chemistry, 43(12), 2480-2482 (1978)
Young-Keun Yang et al.
Nature protocols, 2(7), 1740-1745 (2007-07-21)
This protocol describes detailed procedures for the preparation of a rhodamine-based mercury probe and for its applications to the detection of mercury in cells and vertebrate organisms. The mercury probe 1, which is prepared in two steps from rhodamine 6G

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TiO2 exhibits wide band gap semiconductor and memristor properties electronically, with high opacity and UV absorbance optically.

Questions

1–10 of 13 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. Is this product DNase and RNase-free?

    1 answer
    1. This product is not tested for DNase or RNase. Note that products D9170, D8418, or 41639 are tested for DNase and RNase content.

      Helpful?

  3. can i use it in cell culturing

    1 answer
    1. This product has not been tested for suitability in cell culture. Please see the link below to review cell culture tested DMSO product options:
      https://www.sigmaaldrich.com/product/sigma/d2650
      https://www.sigmaaldrich.com/product/sigma/d2438
      https://www.sigmaaldrich.com/product/sigma/d4540

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  5. Hello, I am Kui. I bought a DMSO anhydrous solvent from Sigma Aldrich Inc (CAS#: 67-68-5). I would like to know if there is inert gas inside the bottle. What kind of inert gas is it? Many thanks

    1 answer
    1. Yes, this product is flushed with nitrogen.

      Storage information can be accessed in the SDS available at this link: https://www.sigmaaldrich.com/US/en/sds/sial/276855

      Helpful?

  6. Is Dimethyl sulfoxide a sterile product?

    1 answer
    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

      Helpful?

  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  8. What is the DMSO dissolved in?

    1 answer
    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

      Helpful?

  9. What is Sure/Seal™ packaging?

    1 answer
    1. The Aldrich Sure/Seal™ packaging system is useful in the handling and storage of air-sensitive reagents.

      Helpful?

  10. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer
    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

1–10 of 13 Questions  

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