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Merck

T0500000

Tetracaine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C15H24N2O2 · HCl
Numéro CAS:
136-47-0
Poids moléculaire :
300.82
Numéro MDL:
MFCD00038912
Code UNSPSC :
41116107
ID de substance PubChem :
329826608
Nomenclature NACRES :
NA.24

Principaux documents

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Qualité

pharmaceutical primary standard

Famille d'API

tetracaine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

Clé InChI

PPWHTZKZQNXVAE-UHFFFAOYSA-N

Informations sur le gène

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Cet article
1650006T7508PHR1129
Tetracaine hydrochloride European Pharmacopoeia (EP) Reference Standard

T0500000

Tetracaine hydrochloride

Tetracaine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1650006

Tetracaine hydrochloride

Tetracaine hydrochloride ≥99%

Sigma-Aldrich

T7508

Tetracaine hydrochloride

Tetracaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1129

Tetracaine hydrochloride

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

API family

tetracaine

API family

tetracaine

API family

-

API family

tetracaine

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-30°C

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Actions biochimiques/physiologiques

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit comparable

Réf. du produit
Description
Tarif

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1650006

Tetracaine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1649991

Tetracaine, United States Pharmacopeia (USP) Reference Standard

1650017

Tetracaine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1650028

Tetracaine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1466572

4-Nitrobenzoic acid, United States Pharmacopeia (USP) Reference Standard

Y0002117

Tetracaine, European Pharmacopoeia (EP) Reference Standard

PHR9019

4-Aminobenzyl alcohol, reference material

PHR9024

3-Aminobenzyl alcohol, reference material

PHR2236

Tetracaine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2261

Tetracaine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2339

4-Nitrobenzoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3140

Tetracaine, pharmaceutical secondary standard, certified reference material

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H319,H336

Classification des risques

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Thomas B Marriott et al.
Clinical therapeutics, 34(10), 2174-2183 (2012-09-05)
The lidocaine/tetracaine heated patch is typically applied to the skin for 20 to 30 minutes to provide local dermal analgesia prior to venous access or minor dermatologic procedures. The potential exists for the use of multiple heated patches for longer
Yue Jiang et al.
International journal of pharmaceutics, 436(1-2), 806-814 (2012-08-09)
The aggregation behavior of the cationic drug/anionic surfactant vesicles formed by tetracaine hydrochloride (TH) and double-chain surfactant, sodium bis(2-ethylhexyl)sulfosuccinate (AOT), was investigated. By controlling the molar ratio of TH to AOT, a transition from catanionic vesicles to micelles was observed.
Helen Giannakopoulos et al.
Journal of the American Dental Association (1939), 143(8), 872-880 (2012-08-03)
The authors evaluated the cardiovascular effects and pharmacokinetics of an intranasal 3 percent tetracaine/0.05 percent oxymetazoline spray developed to provide needle-free anesthesia of maxillary teeth. The authors administered to 12 participants a proposed maximum recommended dose (MRD) (18 milligrams tetracaine/0.3
Patrick E McCleskey et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(1 Pt 1), 82-91 (2013-01-03)
Few published studies have analyzed serum lidocaine levels and individual patient characteristics affecting metabolism after application of compounded topical anesthetics. To measure serum lidocaine levels during and cutaneous side effects after standardized application of 23% lidocaine/7% tetracaine compounded anesthetic to
Gabriel C Gaviola et al.
The Laryngoscope, 123(4), 852-858 (2013-02-14)
Transnasal endoscopy is commonly performed in an outpatient otolaryngology setting. Patients are typically administered a topical anesthetic and decongestant prior to this procedure to alleviate discomfort and improve visualization. There is no consensus on which topical anesthetic is most effective
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