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Merck

27001

Formic acid

greener alternative

puriss., meets analytical specifications of DAC, FCC, 98.0-100%

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About This Item

Linear Formula:
HCOOH
CAS Number:
Molecular Weight:
46.03
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-579-1
Beilstein/REAXYS Number:
1209246
MDL number:

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Product Name

Formic acid, puriss., meets analytical specifications of DAC, FCC, 98.0-100%

InChI key

BDAGIHXWWSANSR-UHFFFAOYSA-N

InChI

1S/CH2O2/c2-1-3/h1H,(H,2,3)

SMILES string

OC=O

agency

suitable for EPA 1633

vapor density

1.6 (vs air)

vapor pressure

44.8 mmHg ( 20 °C)

grade

puriss.

assay

98.0-100%

form

liquid

autoignition temp.

1004 °F

quality

meets analytical specifications of DAC, FCC

expl. lim.

57 %

Quality Level

greener alternative product characteristics

Catalysis
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sustainability

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technique(s)

HPLC: suitable

impurities

≤0.001% heavy metals (as Pb)
≤0.005% non-volatile matter
≤0.05% acetic acid (GC)

refractive index

n20/D 1.370 (lit.)

pH

2.2 (20 °C, 2.2 g/L)

bp

100-101 °C (lit.)

mp

8.2-8.4 °C (lit.)

density

1.22 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg
sulfate (SO42-): ≤40 mg/kg
sulfite (SO32-): ≤50 mg/kg

cation traces

Fe: ≤0.001%
heavy metals (as Pb): ≤0.001%

application(s)

PFAS testing

greener alternative category

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Show Differences

1 of 4

This Item
33015W248703695076
grade

puriss.

grade

-

grade

-

grade

-

assay

98.0-100%

assay

≥98%

assay

≥95%

assay

≥96%

agency

suitable for EPA 1633

agency

reag. Ph. Eur., suitable for EPA 1633

agency

meets purity specifications of JECFA

agency

-

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

pH

2.2 (20 °C, 2.2 g/L)

pH

2.2 (20 °C, 2.2 g/L)

pH

2.2 (20 °C, 2.2 g/L)

pH

2.2 (20 °C, 2.2 g/L)

Application


  • Evaluation of aloins, pH and moisture in aloe leaf gel-based personal care products.: This research assessed the consistency and quality of aloe-based products using advanced analytical chemistry techniques, including formic acid in sample preparation to stabilize pH levels and enhance detection accuracy (Sibhat et al., 2022).

  • Multi-Residue Analysis of Fipronil and Its Metabolites in Eggs by SinChERS-Based UHPLC-MS/MS.: Describes the use of formic acid in the sample preparation phase to improve the extraction and detection of pesticide residues, demonstrating its pivotal role in ensuring food safety (Han et al., 2021).

  • Simultaneous determination of phenolic acids and flavonoids in Artemisiae Argyi Folium by HPLC-MS/MS and discovery of antioxidant ingredients based on relevance analysis.: Illustrates how formic acid was essential for modifying the mobile phase in chromatography, enhancing the resolution and quantification of bioactive compounds (Xia et al., 2019).

  • Evaluation of three different artificial agarwood-inducing methods from Aquilaria sinensis using antimicrobial activity.: This study used formic acid in antimicrobial assays to compare the efficacy of different agarwood induction techniques, highlighting its versatility in bioactive compound analysis (Lei et al., 2019).

  • Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass Spectrometry and Triple-Quadrupole Tandem Mass Spectrometry.: Showcases the application of formic acid in the complex analysis of traditional Chinese medicine, enabling precise quantification and identification of multiple components simultaneously (Zhang et al., 2018).


Other Notes

The article number 27001-4X2.5L-M will be discontinued. Please order the single bottle 27001-2.5L-M which is physically identical with the same exact specifications.
The article number 27001-4X2.5L-R will be discontinued. Please order the single bottle 27001-2.5L-R which is physically identical with the same exact specifications.
The article number 27001-6X1L-R will be discontinued. Please order the single bottle 27001-1L-R which is physically identical with the same exact specifications.

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalysis. Click here for more information.

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

118.4 °F - closed cup

flash_point_c

48 °C - closed cup


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Certificates of Analysis (COA)

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Oxidation of formic acid in acid solution on Pt single-crystal electrodes.
Kita H and Lei H-W.
Journal of Electroanalytical Chemistry, 388(1), 167-177 (1997)
Crossover of formic acid through Nafion membranes.
Rhee Y-W, et al.
Journal of Power Sources, 117(1), 35-38 (2003)
Elastic electron scattering from formic acid (HCOOH): absolute differential cross-sections.
Vizcaino V, et al.
New Journal of Physics, 8(6), 85-85 (2006)
Heng Lu et al.
Cell communication insights, 5, 1-7 (2014-05-20)
Protein-protein interactions play a pivotal role in both inter- and intra-cellular signaling. Identification of signaling protein complexes can thus shed important new insights into cell communications. We developed a parallel affinity precipitation protocol to overcome the disadvantages of the tandem
J Liesivuori et al.
Pharmacology & toxicology, 69(3), 157-163 (1991-09-01)
Metabolism of methanol, methyl ethers, esters and amides give rise to formic acid. This acid is an inhibitor of the mitochondrial cytochrome oxidase causing histotoxic hypoxia. Formic acid is a weaker inhibitor than cyanide and hydrosulphide anions. The body burden

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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