Active thionium species mediated functionalization at the 2α-position of indole derivatives.

Active thionium species mediated functionalization at the 2α-position of indole derivatives.

Chemical communications (Cambridge, England) (2011-05-11)

Kazuhiro Higuchi, Masanori Tayu, Tomomi Kawasaki

ZUSAMMENFASSUNG

A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

106232

Sigma-Aldrich

Trifluoressigsäureanhydrid, ReagentPlus^®, ≥99%

91719

Supelco

Trifluoressigsäureanhydrid, derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)