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  • Pharma and biopharma manufacturing, Monoclonal antibody manufacturing

    Characterization of Monoclonal Antibodies and Antibody Drug Conjugates by Surface Plasmon Resonance

    Characterization of therapeutic monoclonal antibodies (mAbs) or Antibody drug conjugates (ADCs) is challenging due to their ability to bind to a variety of proteins via their Fc and Fab domains, giving rise to diverse biological functions associated with each domain. The Fc domain of mAbs interacts with Fc receptors with varying affinities, which can influence biological processes such as Complement-dependent cytotoxicity (CDC) and Antibody-dependent cellular cytotoxicity (ADCC), transcytosis, phagocytosis, and/or serum half-life.

    Helen Hsu, Ph.D.

    Merck

    Principal Scientist, Process and Analytical Development

    Duration:
    1hr
    Language:
    English
    Session 1:
    Thu, December 8, 202210:00 AM PT
    Learn More