- Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Organic & biomolecular chemistry (2012-11-08)
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
PMID23132282
ZUSAMMENFASSUNG
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
Sigma-Aldrich
D-Sorbit, ≥98% (GC), BioReagent, suitable for cell culture, suitable for plant cell culture
Sorbit, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Sorbit F -Lösung, 70 wt. % in H2O, Contains mainly D-sorbitol with lesser amounts of other hydrogenated oligosaccharides