Anodic electrochemical oxidation of cholic acid.

Anodic electrochemical oxidation of cholic acid.

Steroids (2001-01-09)

A Medici, P Pedrini, A De Battisti, G Fantin, M Fogagnolo, A Guerrini

ZUSAMMENFASSUNG

Regioselectivity in the anodic electrochemical oxidation of cholic acid with different anodes is described. The oxidation with PbO(2) anode affords the dehydrocholic acid in quantitative yield after 22 h. 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic acid (59%) and 3alpha-hydroxy-7,12-dioxo-5beta-cholan-24-oic acid (51%) are obtained stopping the reaction at lower time. The rate of the OH-oxidation is C7 > C12 > C3. The electro-oxidation with platinum foil anode gives selectively the 7-ketocholic acid in 40% yield. On the other hand, the graphite plate anode, varying the reaction conditions, produces selectively the dehydrocholic acid in quantitative yield or the 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid (96%) while the 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid (34%) is obtained together with the other oxo acids.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

GF90182257

Platin, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

GF82419408

Platin, foil, 50x50mm, thickness 0.125mm, as rolled, 99.95%

GF33254793

Platin, foil, 25x25mm, thickness 0.1mm, as rolled, 99.95%

GF98759200

Platin, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

GF35428406

Platin, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%

GF61497658

Platin, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95%

GF72819715

Platin, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%

GF30259357

Platin, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%

GF14510359

Platin, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.95%

GF05831120

Platin, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99.95%

GF92036235

Platin, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%

GF60279576

Platin, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

GF04529538

Platin, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF92049891

Platin, foil, not light tested, 25x25mm, thickness 0.0025mm, as rolled, 99.95%

GF72782231

Platin, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

GF31105864

Platin, foil, 10mm disks, thickness 0.025mm, as rolled, 99.95%

GF65523034

Platin, foil, 10mm disks, thickness 0.1mm, as rolled, 99.99+%

GF48496977

Platin, foil, 4mm disks, thickness 0.125mm, as rolled, 99.99+%

GF36721762

Platin, foil, not light tested, 100x100mm, thickness 0.0025mm, as rolled, 99.95%

GF37788452

Platin, foil, not light tested, 25x25mm, thickness 0.01mm, as rolled, 99.95%

GF52808025

Platin, foil, 0.1m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%

GF51291592

Platin, foil, 6mm disks, thickness 0.025mm, as rolled, 99.95%

GF87686173

Platin, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%

GF91422132

Platin, foil, 0.1m coil, thickness 0.05mm, coil width 1mm, as rolled, 99.99%

GF66494795

Platin, foil, 1.2mm disks, thickness 0.025mm, as rolled, 99.95%

GF43907799

Platin, foil, 15mm disks, thickness 0.005mm, as rolled, 99.95%

GF02102948

Platin, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

GF29558571

Platin, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

GF28802695

Platin, foil, 25x25mm, thickness 0.25mm, as rolled, 99.999%

GF82054492

Platin, foil, 0.1m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%