- Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.
Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.
Molecules (Basel, Switzerland) (2014-12-09)
Myoung-Jun Jang, Ye Sol Kim, Eun Young Bae, Tae-Seok Oh, Hwa-Jung Choi, Jung-Hee Lee, Hyun-Mee Oh, Seung Woong Lee
PMID25486247
ZUSAMMENFASSUNG
Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.
MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
Sigma-Aldrich
Chloroform, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains amylenes as stabilizer
Sigma-Aldrich
Chloroform, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains 0.5-1.0% ethanol as stabilizer
Sigma-Aldrich
Chloroform, ACS spectrophotometric grade, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer
Sigma-Aldrich
Chloroform, contains ethanol as stabilizer, meets analytical specification of BP, 99-99.4% (GC)