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Merck

C1919

Cloramfenicolo

BioReagent, suitable for plant cell culture

Sinonimo/i:

D-(−)-treo-2,2-dicloro-N-[β-idrossi-α-(idrossimetil)-β-(4-nitrofenil)etil]acetammide, D-(−)-treo-2-dicloroacetammido-1-(4-nitrofenil)-1,3-propanediolo, D-treo-2,2-dicloro-N-[β-idrossi-α-(idrossimetil)-4-nitrofenetil]acetammide, Cloromicetina

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5 G

CHF 35.30

25 G

CHF 99.20

100 G

CHF 332.00

CHF 35.30

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Informazioni su questo articolo

Formula condensata:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Numero CAS:
56-75-7
Peso molecolare:
323.13
Beilstein:
2225532
Numero CE:
200-287-4
Numero MDL:
MFCD00078159
Codice UNSPSC:
51102831
ID PubChem:
24892448
NACRES:
NA.76

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Nome Commerciale

BioReagent

Stato

powder

tecniche

cell culture | plant: suitable

Impurezze

Endotoxin, tested

Punto di fusione

149-153 °C (lit.)

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

applicazioni

agriculture

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
WIIZWVCIJKGZOK-RKDXNWHRSA-N

Informazioni sul gene

human ... CYP1A2(1544)

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Questo articolo
31667BP854Y0001869
Cloramfenicolo BioReagent, suitable for plant cell culture

Sigma-Aldrich

C1919

Cloramfenicolo

Cloramfenicolo VETRANAL®, analytical standard

Supelco

31667

Cloramfenicolo

Cloramfenicolo British Pharmacopoeia (BP) Reference Standard

BP854

Cloramfenicolo

Cloramfenicolo European Pharmacopoeia (EP) Reference Standard

Y0001869

Cloramfenicolo

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

technique(s)

cell culture | plant: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

-

product line

BioReagent

product line

VETRANAL®

product line

-

product line

-

form

powder

form

-

form

powder

form

-

Descrizione generale

Chemical structure: phenicole

Applicazioni

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Azioni biochim/fisiol

Modalità d′azione: il cloramfenicolo inibisce la sintesi proteica batterica bloccando il passaggio della peptidil transferasi tramite il legame alla subunità ribosomiale 50S e impedendo il legame dell′amminoacil-tRNA al ribosoma. Inibisce inoltre la sintesi delle proteine mitocondriali e dei cloroplasti e la formazione ribosomiale del (p)ppGpp, deprimendo la trascrizione dell′rRNA.

Modalità di resistenza: l′uso della cloramfenicolo acetiltransferasi acetila il prodotto e lo inattiva.

Spettro antimicrobico: questo è un antibiotico ad ampio spettro contro batteri gram positivi e gram negativi e viene utilizzato principalmente per scopi oftalmici e veterinari.

Nota sulla preparazione

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Altre note

Keep container tightly closed in a dry and well-ventilated place, Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Esclusione di responsabilità

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.

Pittogrammi

Health hazardCorrosion
GHS08,GHS05

Avvertenze

Danger

Indicazioni di pericolo

H318,H351,H361fd

Classi di pericolo

Carc. 2 - Eye Dam. 1 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000474737
0000474737
0000458073
0000458073
0000451673

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Maiken Cavling Arendrup et al.
The Journal of antimicrobial chemotherapy, 75(7), 1807-1819 (2020-04-18)
Terbinafine resistance is increasingly reported in Trichophyton, rendering susceptibility testing particularly important in non-responding cases. We performed a multicentre evaluation of six EUCAST-based methods. Ten laboratories susceptibility tested terbinafine, itraconazole, voriconazole and amorolfine against a blinded panel of 38 terbinafine
Uwe Richter et al.
Current biology : CB, 23(6), 535-541 (2013-03-05)
Proliferating cells require coordinated gene expression between the nucleus and mitochondria in order to divide, ensuring sufficient organelle number in daughter cells [1]. However, the machinery and mechanisms whereby proliferating cells monitor mitochondria and coordinate organelle biosynthesis remain poorly understood.
Anthony J Brzoska et al.
PloS one, 8(2), e56090-e56090 (2013-02-15)
Members of the genus Acinetobacter have been the focus recent attention due to both their clinical significance and application to molecular biology. The soil commensal bacterium Acinetobacter baylyi ADP1 has been proposed as a model system for molecular and genetic
J N de Almeida Júnior et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), 784-790 (2013-12-21)
Trichosporon spp. have recently emerged as significant human pathogens. Identification of these species is important, both for epidemiological purposes and for therapeutic management, but conventional identification based on biochemical traits is hindered by the lack of updates to the species
David G Kirk et al.
Applied and environmental microbiology, 80(16), 5141-5150 (2014-06-15)
Clostridium botulinum produces heat-resistant endospores that may germinate and outgrow into neurotoxic cultures in foods. Sporulation is regulated by the transcription factor Spo0A and the alternative sigma factors SigF, SigE, SigG, and SigK in most spore formers studied to date.
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Articoli

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

Abtötungskurve von Antibiotika

Die Abtötungskurve von Antibiotika ist ein Dosis-Wirkungs-Versuch, in dem Säugerzellen zunehmenden Mengen eines selektiven Antibiotikums ausgesetzt werden

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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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