The solution stability of this product has not been determined. As indicated in the 'DESCRIPTION' section under 'Preparation Note', solutions should be freshly prepared. However, one publication tested the stability of 4.2 mM solutions of MPP+ over 28 days in the dark at 37 °C. Aliquots of the solution were taken and then stored at -80 °C for analysis by HPLC. During this period, no degradation of MPP+ was observed (Yazdani, U., et al., Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+). Exp. Neurol., 200, 172-183 (2006)).
D048
MPP+ iodide
≥98% (HPLC), ERα antagonist, powder
Sinonimo/i:
1-Methyl-4-phenylpyridinium iodide
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 198.00 |
1 g | Per conoscere la disponibilità, visualizza il carrello | CHF 575.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C12H12IN
Numero CAS:
Peso molecolare:
297.13
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
MPP+ iodide, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
SMILES string
[I-].C[n+]1ccc(cc1)-c2ccccc2
InChI
1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key
RFDFRDXIIKROAI-UHFFFAOYSA-M
General description
1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
Application
Biochem/physiol Actions
Active metabolite of dopaminergic neurotoxin MPTP
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
Preparation Note
Solutions should be freshly prepared.
Disclaimer
Photosensitive.
Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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