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D9302

Diacerein

≥95% (HPLC)

Sinonimo/i:

1,8-Diacetoxy-3-carboxyanthraquinone

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C19H12O8
Numero CAS:
13739-02-1
Peso molecolare:
368.29
NACRES:
NA.25
PubChem Substance ID:
24894281
UNSPSC Code:
41116107
EC Number:
237-310-2
MDL number:
MFCD00468030
Assay:
≥95% (HPLC)
Form:
powder

assay

≥95% (HPLC)

form

powder

SMILES string

CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O

InChI

1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)

InChI key

TYNLGDBUJLVSMA-UHFFFAOYSA-N

Biochem/physiol Actions

Diacerin is an inhibitor of Interleukin-1B (IL-1B) production.

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Pittogrammi

Exclamation mark
GHS07

Parola di avvertenza

Warning

Codici di pericolo

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number

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Questions

1–5 of 5 Questions  

  1. What is the melting point of Product D9302, Diacerein?

    1 answer

    1. The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. Can Product D9302, Diacerein, be dissolved in DMSO?

    1 answer

    1. Yes. Diacerein is soluble in DMSO at 1 mg/mL.  The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.

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  4. What is the biological activity of Product D9302, Diacerein?

    1 answer

    1. Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders."  Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".

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  5. What is the mechanism of action of Product D9302, Diacerein?

    1 answer

    1. "Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).

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