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E4642
(±)-Epinephrine hydrochloride
≥98% (TLC), powder, adrenergic receptor agonist
Sinonimo/i:
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C9H13NO3 · HCl
Numero CAS:
Peso molecolare:
219.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-346-0
MDL number:
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Servizio Tecnico
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Permettici di aiutartiNome del prodotto
(±)-Epinephrine hydrochloride,
Quality Segment
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
OC(CNC)C1=CC=C(O)C(O)=C1.Cl
InChI
1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
InChI key
ATADHKWKHYVBTJ-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
General description
Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.
Application
(±)-Epinephrine hydrochloride has been used:
- in the induction of renalase expression in Human renal proximal tubular epithelial cells
- in the infusion studies to test its effect on heart rate and eye temperature measurements in bull
- as a medium supplement for the stimulation of endothelial progenitor cells
Biochem/physiol Actions
Adrenergic receptor agonist.
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.
Other Notes
The ratio of +/- adrenaline is not determined.
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Questo articolo | |||
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| description - | description pharmaceutical secondary standard, certified reference material | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-30°C |
| solubility H2O: 50 mg/mL | solubility - | solubility - | solubility - |
| Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) | Gene Information - | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) |
Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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est ce que l'epinephrine de degrade a 37C et est ce qu'il est reversible?
1 answer-
Helpful?
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
Helpful?
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Hi, Do you have the ratio/ amount of D- and L-adrenaline in this product?
1 answer-
The ratio of +/- adrenaline is not determined.
Helpful?
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