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F9397

Flutamide

Non-steroidal anti-androgen drug

Sinonimo/i:

2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

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1 g
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CHF 124.00
5 g
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CHF 185.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C11H11F3N2O3
Numero CAS:
13311-84-7
Peso molecolare:
276.21
NACRES:
NA.77
PubChem Substance ID:
24278446
UNSPSC Code:
51111800
EC Number:
236-341-9
MDL number:
MFCD00072009

CHF 124.00

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Nome del prodotto

Flutamide,

Quality Segment

originator

Schering Plough

SMILES string

CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI

1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

InChI key

MKXKFYHWDHIYRV-UHFFFAOYSA-N

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro. It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Biochem/physiol Actions

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo
F0285600128585194495
Flutamide

Sigma-Aldrich

F9397

Flutamide

Flutamide European Pharmacopoeia (EP) Reference Standard

F0285600

Flutamide

Flutamide United States Pharmacopeia (USP) Reference Standard

USP

1285851

Flutamide

Flutamide certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

94495

Flutamide

description

-

description

European Pharmacopoeia (EP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

description

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

originator

Schering Plough

originator

-

originator

-

originator

-

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Gene Information

human ... AR(367)

Gene Information

human ... AR(367)

Gene Information

human ... AR(367)

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Parola di avvertenza

Warning

Codici di pericolo

H302,H351,H361,H373,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2

Organi bersaglio

Liver

Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number

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Questions

  1. How Can I prepare 1nM solution of flutamide? flutamide dissolves in ethanol? AFTER DISSOLVING flutamide IN ETHANOL , WHATS the storage conditions and useful life?

    1 answer

    1. Flutamide is soluble in ethanol (50 mg/ml) with heat as needed, yielding a clear to hazy, yellow to yellow-green solution. It is also soluble in acetone, ethyl acetate, methanol, chloroform, and ether.

      The molecular weight of flutamide is 276.21, and this value can be used to calculate the amount needed to make a 1nM solution in the desired volume:
      https://www.sigmaaldrich.com/support/calculators-and-apps/mass-molarity-calculator

      Using freshly made solutions whenever possible is always recommended, but storing them at -20°C in non-diluted aliquots should maintain their stability for at least one month.

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