UC304

O-Desmethyltramadol

• Sinonimo/i: 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol, O-Demethyl tramadol
• Formula empirica (notazione di Hill): C₁₅H₂₃NO₂
• Numero CAS: 80456-81-1
• Peso molecolare: 249.35
• NACRES: NA.77
• PubChem Substance ID: 329827665
• UNSPSC Code: 12161501
• MDL number: MFCD01311883
• Form: solid

Proprietà

• form: solid
• storage temp.: 2-8°C
• SMILES string: CN(C)C[C@H]1CCCC[C@]1(O)c2cccc(O)c2
• InChI: 1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1
• InChI key: UWJUQVWARXYRCG-HIFRSBDPSA-N

Descrizione

General description

O-Desmethyltramadol, an opioid, is an active metabolite of tramadol. The enzyme key for its production is polymorphic cytochrome P450 isoenzyme 2D6 (CYP2D6).

Application

O-Desmethyltramadol has been used for the pharmacokinetic studies of tramadol metabolites in goats.

O-Desmethyltramadol may be used as an opioid to test its effect on the cytotoxic functionality of human natural killer cells. It may also be used as an internal standard in gas chromatography-mass spectrometry (GC-MS) for the quantification of tramadol based derivatives from human urine samples.

Biochem/physiol Actions

Metabolite of tramadol

O-Desmethyltramadol has a high affinity towards opioid receptors and is responsible for the analgesic effect of the μ-opioid receptor

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS09
• Parola di avvertenza: Danger
• Codici di pericolo: H301,H336,H411
• Avvertenze di sicurezza: P261 - P264 - P270 - P271 - P273 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type N95 (US)